Beilstein J. Org. Chem.2022,18, 1017–1025, doi:10.3762/bjoc.18.102
. Azodyrecins D–G, four new analogs of aliphatic azoxides, were identified from two Streptomyces species by a reactivity-basedscreening that targets azoxy bonds. A biological activity evaluation demonstrated that the double bond in the alkyl side chain is important for the cytotoxicity of azodyrecins. An in
of their biosynthetic mechanisms.
Keywords: biosynthesis; methyltransferase; natural azoxides; reactivity-basedscreening; Streptomyces; Introduction
Azoxy natural products are a rare yet intriguing class of natural products with various beneficial biological properties, such as antibacterial
natural products, despite their notable biological activities.
Reactivity-basedscreening is an emerging strategy in natural products discovery, in which chemical probes are used for the specific detection of the unique functionality of interest in crude metabolites [5][6]. The reactions usually